Deoxycorticosterone acetate

Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria[1][2].

Product Specifications

CAS Number

[56-47-3]

Product Name Alternative

11-Deoxycorticosterone acetate; DOC acetate; Cortexone acetate

UNSPSC

12352211

Hazard Statement

H360, H373

Target

Endogenous Metabolite; Mineralocorticoid Receptor

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Deoxycorticosterone-acetate.html

Purity

99.87

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

C[C@@]12[C@@H](C(COC(C)=O)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O

Molecular Formula

C23H32O4

Molecular Weight

372.50

Precautions

H360, H373

References & Citations

[1]Lu NZ, et al. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol Rev. 2006 Dec;58 (4) :782-97. |[2]Lother A, et al. Deoxycorticosterone Acetate/Salt-Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood Pressure. Hypertension. 2016 Jan;67 (1) :130-8. |[3]M J Somers, et al. Vascular Superoxide Production and Vasomotor Function in Hypertension Induced by Deoxycorticosterone Acetate–Salt. Circulation. 2000 Apr 11;101 (14) :1722-8.|[4]Y Matsumura, et al. Different Contributions of Endothelin-A and Endothelin-B Receptors in the Pathogenesis of Deoxycorticosterone Acetate–Salt–Induced Hypertension in Rats. Hypertension. 1999 Feb;33 (2) :759-65.