(±) -α-Tocopherol nicotinate

(±) -α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±) -α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].

Product Specifications

CAS Number

[51898-34-1]

Product Name Alternative

Rel-Vitamin E Nicotinate

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Reactive Oxygen Species (ROS)

Type

Biochemical Assay Reagents

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/racemic-α-tocopherol-nicotinate.html

Concentration

10mM

Purity

99.77

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=C2C(CC[C@](C)(O2)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C(OC(C3=CN=CC=C3)=O)=C1C)C

Molecular Formula

C35H53NO3

Molecular Weight

535.80

Precautions

H302, H315, H319, H335

References & Citations

[1]T W Chung, et al. Reducing lipid peroxidation stress of erythrocyte membrane by alpha-tocopherol nicotinate plays an important role in improving blood rheological properties in type 2 diabetic patients with retinopathy. Diabet Med. 1998 May;15 (5) :380-5.|[2]Satoru Moriguchi, et al.Vitamin E enhances T cell differentiation through increased epithelial cell function in rat thymus, Nutrition Research, Volume 17, Issue 5,1997, Pages 873-883.