1-Oleoyl lysophosphatidic acid (sodium)

1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) sodium, a potent bioactive phospholipid, is a LPA receptor activator. 1-Oleoyl lysophosphatidic acid sodium can promote mitosis by inducing DNA synthesis. 1-Oleoyl lysophosphatidic acid sodium is also involved in normal and pathological emotional responses, including anxiety and depression[1][2][3].

Product Specifications

CAS Number

[325465-93-8]

Product Name Alternative

1-Oleoyl-sn-glycero-3-phosphate (sodium) ; 1-Oleoyl-LPA (sodium)

UNSPSC

12352211

Hazard Statement

H315, H317, H319, H335, H360

Target

LPL Receptor; Mitosis

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1-oleoyl-lysophosphatidic-acid-sodium.html

Purity

99.80

Solubility

DMSO : 1.85 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 60°C) |H2O : 25 mg/mL (ultrasonic)

Smiles

CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](O)COP(O)(O[Na])=O)=O

Molecular Formula

C21H40NaO7P

Molecular Weight

458.50

Precautions

H315, H317, H319, H335, H360

References & Citations

[1]Corven EJ, et, al. Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin. Biochem J. 1992 Jan 1;281 (Pt 1) (Pt 1) :163-9.|[2]Lapierre DM, et, al. Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J Biol Chem. 2010 Aug 13;285 (33) :25792-801.|[3]Castilla-Ortega E, et, al. 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. PLoS One. 2014 Jan 7;9 (1) :e85348.