SPOP-IN-1
SPOP-IN-1 is a selective SPOP E3 ubiquitin ligase inhibitor. SPOP-IN-1 leads to the accumulation of tumor suppressors PTEN and DUSP7 and decreased levels of phosphorylated AKT and ERK in clear-cell renal cell carcinoma[1].
Product Specifications
CAS Number
[2136270-56-7]
UNSPSC
12352005
Target
Akt; E1/E2/E3 Enzyme; ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spop-in-1.html
Purity
99.71
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC2=C(N(CCC3=CC=CS3)C1=N)N=C4C(C)=CC=CN4C2=O)NCCN5CCN(CC5)C
Molecular Formula
C26H31N7O2S
Molecular Weight
505.64
References & Citations
[1]Dong Z, et al. Structure-Activity Relationship of SPOP Inhibitors against Kidney Cancer. J Med Chem. 2020 May 14;63 (9) :4849-4866.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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