Folinic acid (calcium)
Product Specifications
UNSPSC Description
Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].
Target Antigen
Antifolate; Endogenous Metabolite
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Folinic-acid-Calcium.html
Smiles
O=C(N[C@H](C([O-])=O)CCC([O-])=O)C(C=C1)=CC=C1NCC(N2C=O)CNC3=C2C(N=C(N)N3)=O.[Ca+2]
Molecular Weight
511.50
References & Citations
[1]Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397(2):221-8.|[2]Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.EBioMedicine. 2024 Mar 13:102:105041.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Nat Commun. 2020 Apr 14;11(1):1792.|Appl Microbiol Biotechnol. 2024 Dec;108(1):1-15.|bioRxiv. 2023 Feb 28.|JAMA Oncol. 2022 Jan 1;8(1):e215445.|Mol Oncol. 2020 Nov;14(11):2894-2919.|NPJ Precis Oncol. 2023 Dec 8;7(1):128.|Patent. US20230101335A1.|Virology. 2023 Jun 21.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13664/Folinic-acid-calcium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13664/Folinic-acid-calcium-SDS-MedChemExpress.pdf
CAS Number
1492-18-8
Available Sizes
Curated Selection
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