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Folinic acid (calcium)

Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].

Product Specifications

CAS Number

[1492-18-8]

Product Name Alternative

Leucovorin (calcium) ; Calcium folinate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antifolate; Endogenous Metabolite

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Folinic-acid-Calcium.html

Purity

99.86

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C([O-])=O)CCC([O-])=O)C(C=C1)=CC=C1NCC(N2C=O)CNC3=C2C(N=C(N)N3)=O.[Ca+2]

Molecular Formula

C20H21CaN7O7

Molecular Weight

511.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397 (2) :221-8.|[2]Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92 (12) :1438-44.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Human Endogenous Metabolite

Citation 01

EBioMedicine. 2024 Apr:102:105041.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.|Nat Commun. 2020 Apr 14;11 (1) :1792.|Appl Microbiol Biotechnol. 2024 Dec;108 (1) :1-15.|bioRxiv. 2023 Feb 28.|bioRxiv. 2025 Sep 17.|Int J Immunopathol Pharmacol. 2025 Jan-Dec:39:3946320251338662.|JAMA Oncol. 2022 Jan 1;8 (1) :e215445.|Mol Oncol. 2020 Nov;14 (11) :2894-2919.|NPJ Precis Oncol. 2023 Dec 8;7 (1) :128.|Patent. US20230101335A1.|Virology. 2023 Aug:585:205-214.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.

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