BRD6989
BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes[1].
Product Specifications
CAS Number
[642008-81-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK; Interleukin Related
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/brd6989.html
Purity
99.56
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
N#CC1=C(C2=CC=CN=C2)C3=C(N=C1N)CCC(C)C3
Molecular Formula
C16H16N4
Molecular Weight
264.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Johannessen L, et al. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat Chem Biol. 2017 Oct;13 (10) :1102-1108
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK19; CDK8; IL-10
Available Sizes
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