Gingerenone A
Gingerenone A is an Nrf2-Gpx4 activator that can induce Ferroptosis in liver damage with oral activity. Gingerenone A has anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging effects in mice[1][2][3][4].
Product Specifications
CAS Number
128700-97-0
UNSPSC
12352005
Hazard Statement
H302, H372, H410
Target
Ferroptosis; Glutathione Peroxidase; Keap1-Nrf2
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gingerenone-a.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(/C=C/CCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2
Molecular Formula
C21H24O5
Molecular Weight
356.41
Precautions
H302, H372, H410
References & Citations
[1]Yu TJ, et al. Gingerenone A Induces Antiproliferation and Senescence of Breast Cancer Cells. Antioxidants (Basel) . 2022 Mar 19;11 (3) :587.|[2]Chen Y, et al. Gingerenone A Alleviates Ferroptosis in Secondary Liver Injury in Colitis Mice via Activating Nrf2-Gpx4 Signaling Pathway. J Agric Food Chem. 2022 Oct 5;70 (39) :12525-12534.|[3]Junhong Chen, et al. Gingerenone A Sensitizes the Insulin Receptor and Increases Glucose Uptake by Inhibiting the Activity of p70 S6 Kinase. Mol Nutr Food Res.2018 Dec;62 (23) :e1800709. |[4]Sujin Suk, et al. Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice. Mol Nutr Food Res. 2017 Oct;61 (10) :10.1002/mnfr.201700139.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
GPX4
Available Sizes
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