Gingerenone A

Gingerenone A is an Nrf2-Gpx4 activator that can induce Ferroptosis in liver damage with oral activity. Gingerenone A has anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging effects in mice[1][2][3][4].

Product Specifications

CAS Number

[128700-97-0]

UNSPSC

12352005

Hazard Statement

H302, H372, H410

Target

Ferroptosis; Glutathione Peroxidase; Keap1-Nrf2

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gingerenone-a.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(/C=C/CCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2

Molecular Formula

C21H24O5

Molecular Weight

356.41

Precautions

H302, H372, H410

References & Citations

[1]Yu TJ, et al. Gingerenone A Induces Antiproliferation and Senescence of Breast Cancer Cells. Antioxidants (Basel) . 2022 Mar 19;11 (3) :587.|[2]Chen Y, et al. Gingerenone A Alleviates Ferroptosis in Secondary Liver Injury in Colitis Mice via Activating Nrf2-Gpx4 Signaling Pathway. J Agric Food Chem. 2022 Oct 5;70 (39) :12525-12534.|[3]Junhong Chen, et al. Gingerenone A Sensitizes the Insulin Receptor and Increases Glucose Uptake by Inhibiting the Activity of p70 S6 Kinase. Mol Nutr Food Res.2018 Dec;62 (23) :e1800709. |[4]Sujin Suk, et al. Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice. Mol Nutr Food Res. 2017 Oct;61 (10) :10.1002/mnfr.201700139.