AP 811
AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation[1][2].
Product Specifications
CAS Number
124833-45-0
UNSPSC
12352209
Target
Natriuretic Peptide Receptor (NPR)
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ap-811.html
Purity
99.64
Solubility
H2O : 1.67 mg/mL (ultrasonic; warming; heat to 25°C)
Smiles
NC(NCCC[C@H](NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC(CC(C=C1)=CC=C1NC(C2=CC3=C(C=C2)C=CC=C3)=O)=O)CCCNC(N)=N)=O)[C@@H](C)CC)=O)=O)C(NC[C@@H](C)CC)=O)=N
Molecular Formula
C46H66N12O8
Molecular Weight
915.09
References & Citations
[1]Veale CA, et al. The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett. 2000;10 (17) :1949-1952.|[2]William M, et al. Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am J Physiol Cell Physiol. 2008;294 (4) :C1067-C1073.|[3]Jason R Becker, et al. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development. 2014 Jan;141 (2) :335-45.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP303798L 1 mg
Dystrobrevin beta (DTNB) (NM_183361) Human Recombinant Protein
Sign In for Pricing
View Details 
TP750007 100 µg
TNF alpha (TNF) (NM_000594) Human Recombinant Protein
Sign In for Pricing
View Details 
