AP 811
AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation[1][2].
Product Specifications
CAS Number
124833-45-0
UNSPSC
12352209
Target
Natriuretic Peptide Receptor (NPR)
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ap-811.html
Purity
99.64
Solubility
H2O : 1.67 mg/mL (ultrasonic; warming; heat to 25°C)
Smiles
NC(NCCC[C@H](NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC(CC(C=C1)=CC=C1NC(C2=CC3=C(C=C2)C=CC=C3)=O)=O)CCCNC(N)=N)=O)[C@@H](C)CC)=O)=O)C(NC[C@@H](C)CC)=O)=N
Molecular Formula
C46H66N12O8
Molecular Weight
915.09
References & Citations
[1]Veale CA, et al. The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett. 2000;10 (17) :1949-1952.|[2]William M, et al. Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am J Physiol Cell Physiol. 2008;294 (4) :C1067-C1073.|[3]Jason R Becker, et al. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development. 2014 Jan;141 (2) :335-45.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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