AP 811

AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation[1][2].

Product Specifications

CAS Number

[124833-45-0]

UNSPSC

12352209

Target

Natriuretic Peptide Receptor (NPR)

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ap-811.html

Purity

99.64

Solubility

H2O : 1.67 mg/mL (ultrasonic; warming; heat to 25°C)

Smiles

NC(NCCC[C@H](NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC(CC(C=C1)=CC=C1NC(C2=CC3=C(C=C2)C=CC=C3)=O)=O)CCCNC(N)=N)=O)[C@@H](C)CC)=O)=O)C(NC[C@@H](C)CC)=O)=N

Molecular Formula

C46H66N12O8

Molecular Weight

915.09

References & Citations

[1]Veale CA, et al. The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett. 2000;10 (17) :1949-1952.|[2]William M, et al. Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am J Physiol Cell Physiol. 2008;294 (4) :C1067-C1073.|[3]Jason R Becker, et al. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development. 2014 Jan;141 (2) :335-45.