Anti-CaMKII Antibody

Rabbit Polyclonal Antibody specific to CaMKII

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

CaM kinase II subunit α, CaMK-II subunit α, EC 2.7.11.17

Gene Name

CAMK2A

Gene ID

815

NCBI Gene ID

Accession Number

NP_741960.1

Host

Rabbit

Reactivity

Human, Mouse, Rat, Bovine, Hamster, Guinea Pig, Chicken, Rabbit

Immunogen

Synthetic peptide corresponding to aa 7-20 (N-terminus) of rat CaMKII delta isoform conjugated to KLH.

Target Antigen

Calcium/calmodulin-dependent protein kinase type II subunit α

Target

CaMKII

Clonality

Polyclonal

Type

Antibody

Applications

Field of Research

Enzymes

Purification Method

Purified by protein A affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Additionnal Information

Immunoblotting: Use at 1-5ug/mL. A band of ~50-60 kDa is detected. Immunohistochemistry: use at 1-10ug/mL. These are recommended concentrations. Endusers should determine optimal concentrations for their applications.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C.

Specificity

CaMKII

Formulation

PBS, 50% glycerol, 0.09% sodium azide.

Target Background

Calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine-specific protein kinase that is regulated by the Ca2+/calmodulin complex. CaMKII is involved in many signaling cascades and is thought to be an important mediator of learning and memory. CaMKII is also necessary for Ca2+ homeostasis and reuptake in cardiomyocytes, chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CaMKII has 28 different isoforms that derive from the alpha, beta, gamma, and delta genes. Misregulation of CaMKII is linked to Alzheimer's disease, Angelman syndrome, and heart arrhythmia.