Cryptanoside A
Cryptanoside A, a cardiac glycoside epoxide, can be isolated from the stems of Cryptolepis dubia. Cryptanoside A has potent cytotoxicity against cancer cells. Cryptanoside A also inhibits Na+/K+-ATPase activity. Cryptanoside A increases the expression of Akt and the p65 subunit of NF-κB[1].
Product Specifications
CAS Number
98570-81-1
UNSPSC
12352005
Target
Akt; Na+/K+ ATPase; NF-κB
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; NF-κB; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cryptanoside-a.html
Solubility
10 mM in DMSO
Smiles
O[C@@]([C@@]1(C2=O)C)(CC[C@]1([H])C(CO3)=CC3=O)[C@]4([C@@](C[C@]5([H])C[C@H]6O[C@H](O[C@H]7C)C[C@@H]([C@H]7O)OC)([H])O4)[C@@]([C@@H]2O)([H])[C@]5(CC6)C
Molecular Formula
C30H42O10
Molecular Weight
562.65
References & Citations
[1]Ren Y, et al. The Cytotoxic Cardiac Glycoside (-) -Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets. J Nat Prod. 2023 Jun 23;86 (6) :1411-1419.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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