Nitracrine (dihydrochloride hydrate)

Nitracrine dihydrochloride hydrate inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine dihydrochloride hydrate, a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine dihydrochloride hydrate has cytotoxicity towards most cells[1][2][3].

Product Specifications

CAS Number

[55429-45-3]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nitracrine-dihydrochloride-hydrate.html

Solubility

10 mM in DMSO

Smiles

CN(C)CCCNC1=C(C([N+]([O-])=O)=CC=C2)C2=NC3=C1C=CC=C3.Cl.O.Cl

Molecular Formula

C18H24Cl2N4O3

Molecular Weight

415.31

References & Citations

[1]Wilson WR, et al. Selective toxicity of nitracrine to hypoxic mammalian cells. Br J Cancer. 1984 Feb;49 (2) :215-23.|[2]Gniazdowski M, et al. Nitracrine and its congeners--an overview. Gen Pharmacol. 1995 May;26 (3) :473-81.Gniazdowski M, et al. NitracrineGniazdowski M, et al. Nitracrine and its congeners--an overview. Gen Pharmacol. 1995 May;26 (3) :473-81. and its congeners--an overview. Gen Pharmacol. 1995 May;26 (3) :473-81.|[3]Daghastanli NA, et al. Cytotoxicity of nitroheterocyclic compounds, quinifuryl and nitracrine, towards leukaemic and normal cells on the dark and under illumination with visible light. J Photochem Photobiol B. 2004 Jul 19;75 (1-2) :27-32.