Tenuigenin
Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect[1].
Product Specifications
CAS Number
[2469-34-3]
Product Name Alternative
Senegenin
UNSPSC
12352211
Hazard Statement
H302
Target
Bacterial; NF-κB
Type
Natural Products
Related Pathways
Anti-infection; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tenuigenin.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
C[C@@]([C@](CC1)([H])[C@]2(C)C(O)=O)(C[C@H](O)[C@@H]2O)[C@](C[C@H](CCl)C3=C4CC[C@]5(C(O)=O)[C@@]3([H])CC(C)(C)CC5)([H])[C@]41C
Molecular Formula
C30H45ClO6
Molecular Weight
537.13
Precautions
H302
References & Citations
[1]Yu B, et al. Protective effects of tenuigenin on Staphylococcus aureus-induced pneumonia in mice. Microb Pathog. 2017 Sep;110:385-389.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
NF-κB
Available Sizes
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