Ophthalmic acid

Ophthalmic acid, an analogue of GSH, is a marker of oxidative stress and hepatic GSH consumption. Ophthalmic acid is an inhibitor of Glyoxalase I reaction[1][2].

Product Specifications

CAS Number

[495-27-2]

UNSPSC

12352211

Hazard Statement

H225, H319

Target

Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ophthalmic-acid.html

Concentration

10mM

Purity

99.17

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC(CNC([C@H](CC)NC(CC[C@H](N)C(O)=O)=O)=O)=O

Molecular Formula

C11H19N3O6

Molecular Weight

289.29

Precautions

H225, H319

References & Citations

[1]Gurnit Kaur, et al. Detection of Ophthalmic Acid in Serum from Acetaminophen-Induced Acute Liver Failure Patients Is More Frequent in Non-Survivors. PLoS One. 2015 Sep 25;10 (9) :e0139299. |[2]E E CLIFFE, et al. The mechanism of the glyoxalase I reaction, and the effect of ophthalmic acid as an inhibitor. Biochem J. 1961 Jun;79 (3) :475-82.