Retro-2 cycl
Retro-2 cycl (RN 1-001) is a retrograde transport inhibitor with antiviral activity. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudoviruses, with an IC50 of 54 μM and 160 μM respectively[1][2][3].
Product Specifications
CAS Number
1429192-00-6
Product Name Alternative
RN 1-001
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Arenavirus; HPV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Retro-2_cycl.html
Concentration
10mM
Purity
99.17
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C1C2=CC=CC=C2NC(N1C3=CC=CC=C3)C4=CC=C(S4)C
Molecular Formula
C19H16N2OS
Molecular Weight
320.41
Precautions
H315, H319, H320
References & Citations
[1]Carney DW, et al. Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses. Bioorg Med Chem. 2014 Sep 1;22 (17) :4836-47.|[2]Wen Dai, et al. Antiviral Effect of Retro-2.1 against Herpes Simplex Virus Type 2 In Vitro. J Microbiol Biotechnol. 2018 Jun 28;28 (6) :849-859.|[3]Wenwen Dai, et al. Antiviral effects of Retro-2cycl and Retro-2.1 against Enterovirus 71 in vitro and in vivo. Antiviral Res. 2017 Aug:144:311-321.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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