Retro-2 cycl

Retro-2 cycl (RN 1-001) is a retrograde transport inhibitor with antiviral activity. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudoviruses, with an IC50 of 54 μM and 160 μM respectively[1][2][3].

Product Specifications

CAS Number

[1429192-00-6]

Product Name Alternative

RN 1-001

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Arenavirus; HPV; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Retro-2_cycl.html

Concentration

10mM

Purity

99.17

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C1C2=CC=CC=C2NC(N1C3=CC=CC=C3)C4=CC=C(S4)C

Molecular Formula

C19H16N2OS

Molecular Weight

320.41

Precautions

H315, H319, H320

References & Citations

[1]Carney DW, et al. Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses. Bioorg Med Chem. 2014 Sep 1;22 (17) :4836-47.|[2]Wen Dai, et al. Antiviral Effect of Retro-2.1 against Herpes Simplex Virus Type 2 In Vitro. J Microbiol Biotechnol. 2018 Jun 28;28 (6) :849-859.|[3]Wenwen Dai, et al. Antiviral effects of Retro-2cycl and Retro-2.1 against Enterovirus 71 in vitro and in vivo. Antiviral Res. 2017 Aug:144:311-321.