BmK-M1

BmK-M1 is a scorpion toxin, and is composed of 64 amino acids cross-linked by four disulfide bridges. BmK-M1 inhibits Na+ channel and can be considered both as a cardiotoxin and a neurotoxin[1].

Product Specifications

UNSPSC

12352209

Target

Sodium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bmk-m1.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)C(C)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NC(C(NC(C(NC(C(NC(C(NC(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]2CC3=CC=C(O)C=C3)=O)=O)CO)=O)CCCCN)=O)C)=O)=O)CC(N)=O)=O)CCCCN)=O)[C@@H](C)O)=O)CSSC[C@H](NC4=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N6[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N7[C@H](C(NCC(N[C@H]8CCCCN)=O)=O)CCC7)=O)C(C)C)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CCC6)=O)C(C)C)=O)CC(N)=O)=O)CC(O)=O)=O)CCC5)=O)CC(C)C)=O)CCC(O)=O)=O)[C@H](CC)C)=O)=O)CC(C)C)=O)CC(O)=O)=O)CC(N)=O)=O)CSSC[C@H](N9)C(N[C@H]4CC%10=CNC%11=CC=CC=C%10%11)=O)=O)CC%12=CC=C(O)C=C%12)=O)CCC(O)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC9=O)=O)CC(N)=O)=O)=O)CC%13=CC=C(O)C=C%13)=O)CCCCN)=O)=O)C(C)C)=O)CC%14=CNC%15=CC=CC=C%14%15)=O)CCC(N)=O)=O)=O)CCC(O)=O)=O)CC%16=CC=C(O)C=C%16)=O)C(C)C)=O)CSSC[C@H](NC8=O)C(N[C@H](C(O)=O)CC%17=CNC=N%17)=O)=O)CC(N)=O)=O)CC%18=CNC=N%18)=O)CCC1)=O)CCCCN)=O)C)=O)[C@H](CC)C)=O)CC%19=CC=C(O)C=C%19)=O)C)=O)CC(O)=O)=O)CCCNC(N)=N

Molecular Formula

C313H467N91O91S8

Molecular Weight

7217.13

References & Citations

[1]C Goudet, et al. Electrophysiological characterization of BmK M1, an alpha-like toxin from Buthus martensi Karsch venom. FEBS Lett. 2001 Apr 20;495 (1-2) :61-5.