Cidofovir (dihydrate)

Cidofovir (GS 0504; HPMPC; (S) -HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer[1][3]. Cidofovir dihydrate also has anti-orthopoxvirus and anti-variola activities[4].

Product Specifications

CAS Number

[149394-66-1]

Product Name Alternative

GS 0504 (dihydrate) ; HPMPC (dihydrate) ; (S) -HPMPC (dihydrate)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; CMV; DNA/RNA Synthesis; Endogenous Metabolite; Orthopoxvirus

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/cidofovir-dihydrate.html

Solubility

10 mM in DMSO

Smiles

OC[C@@H](OCP(O)(O)=O)CN1C=CC(N)=NC1=O.O.O

Molecular Formula

C8H18N3O8P

Molecular Weight

315.22

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]David J Maggs, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65 (4) :399-403.|[2]M Bray, et al. Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge. J Infect Dis. 2000 Jan;181 (1) :10-9.|[3] Simona Catalani, et al. Reduced cell viability and apoptosis induction in human thyroid carcinoma and mesothelioma cells exposed to cidofovir. Toxicol In Vitro. 2017 Jun;41:49-55.|[4]Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57 (1-2) :13-23.