Glutarimide-Isoindolinone-NH-PEG3-COOH
Glutarimide-Isoindolinone-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology[1].
Product Specifications
CAS Number
2803819-65-8
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/glutarimide-isoindolinone-nh-peg3-cooh.html
Purity
99.12
Solubility
DMSO : 30 mg/mL (ultrasonic)
Smiles
O=C1N(CC2=CC(NCCOCCOCCOCCC(O)=O)=CC=C21)C3C(NC(CC3)=O)=O
Molecular Formula
C22H29N3O8
Molecular Weight
463.48
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-1007.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Frequently Asked Questions
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