Glutarimide-Isoindolinone-NH-PEG3-COOH

Glutarimide-Isoindolinone-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

[2803819-65-8]

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/glutarimide-isoindolinone-nh-peg3-cooh.html

Purity

99.12

Solubility

DMSO : 30 mg/mL (ultrasonic)

Smiles

O=C1N(CC2=CC(NCCOCCOCCOCCC(O)=O)=CC=C21)C3C(NC(CC3)=O)=O

Molecular Formula

C22H29N3O8

Molecular Weight

463.48

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-1007.