Yoda 1

Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF) . Yoda 1 enhances Ca2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation[1][2][3].

Product Specifications

CAS Number

[448947-81-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; ERK; Piezo Channel; Potassium Channel

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/GlyT2-IN-1.html

Purity

99.97

Solubility

DMSO : 15.62 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 5 mg/mL (ultrasonic) |Methanol : 2.5 mg/mL (ultrasonic)

Smiles

ClC1=C(CSC2=NN=C(C3=NC=CN=C3)S2)C(Cl)=CC=C1

Molecular Formula

C13H8Cl2N4S2

Molecular Weight

355.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Syeda R, et al. Chemical activation of the mechanotransduction channel Piezo1. Elife. 2015 May 22;4.|[2]Dela Paz NG, et al. Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun. 2018 Feb 26;497 (1) :220-225. |[3]Kuriyama M, et al. Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells. Sci Rep. 2022 Apr 15;12 (1) :6322.