Irisquinone

Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks[1][2][3].

Product Specifications

CAS Number

[56495-82-0]

UNSPSC

12352211

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/irisquinone.html

Solubility

10 mM in DMSO

Smiles

O=C1C(CCCCCCCCC/C=C\CCCCCC)=CC(C=C1OC)=O

Molecular Formula

C24H38O3

Molecular Weight

374.56

References & Citations

[1]Xu H, et al. Dynamic observation of the radiosensitive effect of irisquinone on rabbit VX2 lung transplant tumors by using fluorine-18-deoxyglucose positron emission tomography/computed tomography. Nucl Med Commun. 2013 Mar;34 (3) :220-8. |[2]Wang H, et al. Radiosensitizing effect of irisquinone on glioma through the downregulation of HIF-1α evaluated by 18F-FDG and 18F-FMISO PET/CT. Nucl Med Commun. 2016 Jul;37 (7) :705-14. |[3]Liang, l., et al. The effect of Irisquinone on the glutathione system and MRP expression of cisplatin-resistant human lung adenocarcinoma cell line (A DDP549) . Chin J Cancer Res 13, 171–175 (2001) .