CVN766
CVN766 is an orally active inhibitor of orexin 1 receptor antagonist with blood-brain permeability with the IC50 values of 8 nM and >10 μM for OX1R and OX2R, respectively. CVN766 can be used for study schizophrenia[1].
Product Specifications
CAS Number
1803557-42-7
UNSPSC
12352005
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cvn766.html
Purity
98.31
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCC1=NC(C(F)(F)F)=CN=C1N[C@@H]2[C@@H](NC(C3=NC=CC=C3N4N=CC=N4)=O)CCC2
Molecular Formula
C20H21F3N8O
Molecular Weight
446.43
References & Citations
[1]Glen A, Bürli RW, Livermore D, Buffham W, Merison S, Rowland AE, Newman R, Fieldhouse C, Miller DJ, Dawson LA, et al. Discovery and first-time disclosure of CVN766, an exquisitely selective orexin 1 receptor antagonist. Bioorg Med Chem Lett. 2024 Mar 1;100:129629.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
OX1 Receptor; OX2 Receptor
Available Sizes
Frequently Asked Questions
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