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PSB-SB-487

PSB-SB-487 is a potent GPR55 antagonist and CB2 agonist with an IC50 value of 0.113 µM for GPR55, and a Ki value of 0.292 µM for human CB2. PSB-SB-487 can be used for researching diabetes, Parkinson’s disease, neuropathic pain, and cancer[1].

Product Specifications

CAS Number

[1399049-81-0]

UNSPSC

12352005

Target

Cannabinoid Receptor; GPR55

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/psb-sb-487.html

Purity

98.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(CC2=CC=CC=C2O)=CC3=C(O)C=C(C(C)(C)CCCCCCC)C=C3O1

Molecular Formula

C26H32O4

Molecular Weight

408.53

References & Citations

[1]Viktor Rempel, et al. Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold. J Med Chem. 2013 Jun 13;56 (11) :4798-810.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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