CDK8-IN-12
Product Specifications
UNSPSC Description
CDK8-IN-12 is an orally active, potent CDK8 inhibitor with a Ki of 14 nM. CDK8-IN-12 has off-target kinase inhibition on GSK-3α, GSK-3β, PCK-θ with Kis of 13 nM, 4 nM, 109 nM, respectively. CDK8-IN-12 shows potent anti-proliferative effects selectively on MV4-11 cell. CDK8-IN-12 is an anti-cancer agent[1].
Target Antigen
CDK; GSK-3; PKC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;PI3K/Akt/mTOR;Stem Cell/Wnt;TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk8-in-12.html
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C1NCCC12CCN(C3=C(C4=CC5=CC=CC=C5O4)C=NC=C3Cl)CC2
Molecular Weight
381.86
References & Citations
[1]Mingfeng Yu, et al. Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation. Eur J Med Chem. 2021 Mar 15;214:113248.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148561/CDK8-IN-12-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148561/CDK8-IN-12-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2613307-67-6
Available Sizes
Curated Selection
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