Simvastatin acid (ammonium)

Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].

Product Specifications

CAS Number

[139893-43-9]

Product Name Alternative

Tenivastatin (ammonium)

UNSPSC

12352211

Hazard Statement

H351, H360, H412

Target

HMG-CoA Reductase (HMGCR) ; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/simvastatin-acid-ammonium.html

Purity

99.70

Solubility

DMSO : 7 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C[C@@H](C[C@@H](CC[C@H]1[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC(C(C)(CC)C)=O)C)C)O)O)[O-].[NH4+]

Molecular Formula

C25H43NO6

Molecular Weight

453.61

Precautions

H351, H360, H412

References & Citations

[1]Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015) . Expert Opin Ther Pat. 2016 Nov;26 (11) :1257-1272.|[2]Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45 (Pt 1) :158-165.