N-Methyldopamine (hydrochloride)

N-Methyldopamine hydrochloride is a precursor of adrenaline in the adrenal medulla. N-Methyldopamine hydrochloride is a modification of the dopamine (DA), and retains agonist activity at the DA1 receptor. N-Methyldopamine hydrochloride remains capable of universal surface coating and secondary reactions using the surface catechols. N-Methyldopamine hydrochloride can be used for heart failure research[1][2][3].

Product Specifications

CAS Number

[62-32-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/n-methyldopamine-hydrochloride.html

Purity

99.12

Solubility

H2O : ≥ 100 mg/mL

Smiles

CNCCC1=CC(O)=C(O)C=C1.Cl

Molecular Formula

C9H14ClNO2

Molecular Weight

203.67

Precautions

H315, H319, H335

References & Citations

[1]Laduron P. N-Methyldopamine (epinine), a precursor of adrenaline in the adrenal medulla. Arch Int Pharmacodyn Ther. 1972 Apr;196:Suppl 196:304-. |[2]Rajfer SI, et al. Effects of long-term therapy with oral ibopamine on resting hemodynamics and exercise capacity in patients with heart failure: relationship to the generation of N-methyldopamine and to plasma norepinephrine levels. Circulation. 1986 Apr;73 (4) :740-8.|[3]Kim Y, et al. Effect of N-Methylation on Dopamine Surface Chemistry. Langmuir. 2022 May 24;38 (20) :6404-6410.