Magnesium sulfate

Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a tocolytic. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in the research of diseases such as preeclampsia/eclampsia[1][2][3][4][5][6].

Product Specifications

CAS Number

[7487-88-9]

UNSPSC

12352200

Hazard Statement

H371

Target

Biochemical Assay Reagents; Calcium Channel; COX; Interleukin Related; NF-κB; NO Synthase; Phospholipase

Type

Biochemical Assay Reagents

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/magnesium-sulfate.html

Purity

99.03

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

[Mg]=S(O[O])([O])=O

Precautions

H371

References & Citations

[1]Okusanya BO, et al. Clinical pharmacokinetic properties of magnesium sulphate in women with pre-eclampsia and eclampsia. BJOG. 2016;123 (3) :356-366. |[2]Ramsey PS, et al. Magnesium sulfate as a tocolytic agent. Semin Perinatol. 2001;25 (4) :236-247.|[3]Hurd WW, et al. Magnesium sulfate inhibits the oxytocin-induced production of inositol 1,4,5-trisphosphate in cultured human myometrial cells. Am J Obstet Gynecol. 2002 Aug;187 (2) :419-24. |[4]Lin CY, et al. L-type calcium channels are involved in mediating the anti-inflammatory effects of magnesium sulphate. Br J Anaesth. 2010 Jan;104 (1) :44-51.|[5]Burd I, et al. Magnesium sulfate reduces inflammation-associated brain injury in fetal mice. Am J Obstet Gynecol. 2010 Mar;202 (3) :292.e1-9.|[6]Hunter LA, et al. Magnesium sulfate: past, present, and future. J Midwifery Womens Health. 2011 Nov-Dec;56 (6) :566-74.