δ-Secretase inhibitor 11
Selected Variant
HY-124832-01
Size: 10 mg
δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research[1].
Product Specifications
CAS Number
842964-18-5
UNSPSC
12352005
Hazard Statement
H319, H332, H335
Target
Amyloid-β; Caspase
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/δ-secretase-inhibitor-11.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
NC1=CC=C(N2CCOCC2)C3=NON=C31
Molecular Formula
C10H12N4O2
Molecular Weight
220.23
Precautions
H319, H332, H335
References & Citations
[1]Zhang Z, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017 Mar 27;8:14740.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 8
Available Sizes
Price
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD56 / NCAM (NCAM1/795), CF594 conjugate, 0.1mg/mL
Anti-IMP4 Antibody Picoband®, Dylight550 Conjugate
Chromogranin A / CHGA (Neuroendocrine Marker) (rCHGA/777), 0.2mg/mL
NKX2.8 (NKX28/2547), CF568 conjugate, 0.1mg/mL
