δ-Secretase inhibitor 11

δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research[1].

Product Specifications

CAS Number

[842964-18-5]

UNSPSC

12352005

Hazard Statement

H319, H332, H335

Target

Amyloid-β; Caspase

Type

Reference compound

Related Pathways

Apoptosis; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/δ-secretase-inhibitor-11.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

NC1=CC=C(N2CCOCC2)C3=NON=C31

Molecular Formula

C10H12N4O2

Molecular Weight

220.23

Precautions

H319, H332, H335

References & Citations

[1]Zhang Z, et al. Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun. 2017 Mar 27;8:14740.