Stellettin B
Product Specifications
CAS Number
184885-91-4
UNSPSC Description
Stellettin B is a triterpenoid compound that can be isolated from the marine sponge Jaspis stellifera. Stellettin B induces G1 phase arrest, apoptosis, and autophagy in human non-small cell lung cancer A549 cells by blocking the PI3K/Akt/mTOR pathway. Stellettin B can reduce the migration and invasion of liver cancer cells by decreasing the activation of the MAPK and FAK/PI3K/AKT/mTOR signaling pathways. Stellettin B can be used in the study of various tumors[1][2].
Target Antigen
Akt; Apoptosis; Autophagy; FAK; mTOR; PI3K
Type
Natural Products
Related Pathways
Apoptosis;Autophagy;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stellettin-b.html
Smiles
C[C@@]12[C@](CC(/C2=C(C)\C=C\C=C(C(O3)=CC=C(C)C3=O)/C)=O)([H])[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC1)C
Molecular Weight
462.62
References & Citations
[1]Wang R, et al. Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway. Sci Rep. 2016 May 31;6:27071. |[2]Tsai TC, et al. Stellettin B Isolated from Stelletta Sp. Reduces Migration and Invasion of Hepatocellular Carcinoma Cells through Reducing Activation of the MAPKs and FAK/PI3K/AKT/mTOR Signaling Pathways. Int J Cell Biol. 2022 Nov 29;2022:4416611.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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