Mca-Lys-Pro-Leu-Gly-Leu-Dap (Dnp) -Ala-Arg-NH2

Mca-Lys-Pro-Leu-Gly-Leu-Dap (Dnp) -Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap (Dnp) -Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap (Dnp) -Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13) and MT1-MMP with higher specificity constants than FS-1[1]. (Ex/Em=325 nm/400 nm)

Product Specifications

CAS Number

[720710-69-0]

Product Name Alternative

Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2

UNSPSC

12352209

Target

MMP

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mca-lys-pro-leu-gly-leu-dap-dnp-ala-arg-nh2.html

Purity

99.72

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)CNC2=C(C=C(C=C2)[N+]([O-])=O)[N+]([O-])=O)=O)=O)=O)=O)[C@H](CCCCN)NC(CC(C3=CC=C(OC)C=C3O4)=CC4=O)=O

Molecular Formula

C55H80N16O16

Molecular Weight

1221.32

References & Citations

[1]Neumann U, et al. Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme. Anal Biochem. 2004 May 15;328 (2) :166-73.