Neurotensin

Neurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors (NTR) .

Product Specifications

CAS Number

[39379-15-2]

UNSPSC

12352209

Target

Neurotensin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Neurotensin.html

Purity

99.47

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC([C@@H](N1)CCC1=O)=O)CC(C)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)[C@H](CC)C)=O)CC4=CC=C(O)C=C4)=O)CCC3)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC2)=O)CCCCN)=O)CC(N)=O)=O)CCC(O)=O)=O)CC5=CC=C(O)C=C5

Molecular Formula

C78H121N21O20

Molecular Weight

1672.92

References & Citations

[1]Wang X, et al. Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells. Clin Cancer Res. 2006 Sep 15;12 (18) :5346-55.