Coclaurine

Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum with anticancer activity. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist. Coclaurine is a key molecule in S. tetrandra responsible for EFHD2 inhibition. Coclaurine can downregulate EFHD2-related NOX4-ABCC1 signaling and enhanced Cisplatin (HY-17394) sensitivity. Coclaurine suppresses the stemness and metastatic properties of NSCLC cells. Coclaurine disrupts the interaction between the transcription factor FOXG1 and the EFHD2 promoter, leading to a reduction in EFHD2 transcription[1][2][3][4].

Product Specifications

CAS Number

[486-39-5]

UNSPSC

12352005

Target

NAChR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/coclaurine.html

Purity

98.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC2=C(C=C1OC)CCN[C@H]2CC3=CC=C(O)C=C3

Molecular Formula

C17H19NO3

Molecular Weight

285.34

References & Citations

[1]Sowemimo BO, et al. The isolation of stepharine and coclaurine from Sarcopetalum harveyanum. Lloydia. 1972 Mar;35 (1) :90-1.|[2]Matthew J. Cheesman . Oceania: Antidepressant Medicinal Plants. Herbal Medicine in Depression. 2016, 483-527.|[3]Al-Zahrani, M. H. and Alghamdi, R. A. (2022) “In Silico Molecular Docking Analysis of the Potential role of Reticuline and Coclaurine as Anti-colorectal Cancer Alkaloids”, Journal of Pharmaceutical Research International, 34 (1A), pp. 33–42.|[4]Hu, S. Y., et al., (2024) . Stephania tetrandra and Its Active Compound Coclaurine Sensitize NSCLC Cells to Cisplatin through EFHD2 Inhibition. Pharmaceuticals (Basel, Switzerland), 17 (10), 1356.