Bonducellin
Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L) [1].
Product Specifications
CAS Number
[83162-84-9]
UNSPSC
12352005
Target
Bacterial
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/bonducellin.html
Solubility
10 mM in DMSO
Smiles
O=C1/C(COC2=CC(O)=CC=C12)=C/C3=CC=C(OC)C=C3
Molecular Formula
C17H14O4
Molecular Weight
282.29
References & Citations
[1]Roy SK, et al. 7-Hydroxy- (E) -3-phenylmethylene-chroman-4-one analogues as efflux pump inhibitors against Mycobacterium smegmatis mc² 155. Eur J Med Chem. 2013 Aug;66:499-507.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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