Abaperidone (hydrochloride)

Abaperidone hydrochloride is a potent antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM.

Product Specifications

CAS Number

[183849-45-8]

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/abaperidone-hydrochloride.html

Smiles

O=C1C2=CC=C(C=C2OC=C1CO)OCCCN3CCC(CC3)C4=NOC5=C4C=CC(F)=C5.Cl

Molecular Formula

C25H26ClFN2O5

Molecular Weight

488.94

References & Citations

[1]Bolós J, et al. 7-[3- (1-piperidinyl) propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4- (6-fluoro-1, 2-benzisoxazol-3-yl) -piperidin-1-yl]propoxy]-3- (hydroxymeth yl) chromen -4-one (abaperidone, FI-8602) . J Med Chem. 1998 Dec 31;41 (27) :5402-9.