Diosmetin-d3
Product Specifications
UNSPSC Description
Diosmetin-d3 is the deuterium labeled Diosmetin. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.
Target Antigen
Cytochrome P450; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease;Others
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(O)=C(C=C3)OC([2H])([2H])[2H])=C1
Molecular Weight
303.28
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Liu B, et al. Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells. Mol Med Rep. 2016 Jul;14(1):159-64.|[3]Yu G, et al. Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-κB. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2133-42.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
1189728-54-8
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