Cerebrocrast
Cerebrocrast (IOS-1.1212) is a 1,4-dihydropyridine (DHP) derivative. Cerebrocrast has a high affinity for the membrane lipid bilayer and it can easily penetrate the blood-brain barrier and incorporate into the plasma and organelle membranes, including those of mitochondria. Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria. Cerebrocrast also exhibits neuroprotective and cognition enhancer properties[1][2].
Product Specifications
CAS Number
[118790-71-9]
Product Name Alternative
IOS-1.1212
UNSPSC
12352005
Target
Calcium Channel; Chloride Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cerebrocrast.html
Purity
99.51
Smiles
CCCOCCOC(C1=C(C)NC(C)=C(C(OCCOCCC)=O)C1C2=C(C=CC=C2)OC(F)F)=O
Molecular Formula
C26H35F2NO7
Molecular Weight
511.56
References & Citations
[1]Fernandes MA, et al. Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria. Mitochondrion. 2005 Oct;5 (5) :341-51.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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