Cyclizine

Cyclizine, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine can be used for the research of nausea, vomiting, and dizziness[1][2][3].

Product Specifications

CAS Number

[82-92-8]

UNSPSC

12352005

Hazard Statement

H301

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cyclizine.html

Concentration

10mM

Purity

98.64

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1

Molecular Formula

C18H22N2

Molecular Weight

266.38

Precautions

H301

References & Citations

[1]Králová J, et, al. The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity. Int Immunopharmacol. 2009 Jul;9 (7-8) :990-5.|[2]Church MK, et, al. Inhibition of histamine release from human lung in vitro by antihistamines and related drugs. Br J Pharmacol. 1980 Aug;69 (4) :663-7.|[3]Leza JC, et, al. Effects of antihistaminics on locomotor activity in mice. Comparison with opiate and amphetamine-induced hyperactivity. Gen Pharmacol. 1991;22 (2) :293-6.