16α-Hydroxyprednisolone

16α-Hydroxyprednisolone (OH-PRED) is a stereoselective metabolite of the 22 (R) epimer of the glucocorticoid Budesonide (HY-13580) . 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily[1][2].

Product Specifications

CAS Number

[13951-70-7]

Product Name Alternative

OH-PRED

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/16α-hydroxyprednisolone.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C[C@@]2([C@]3([C@H](C[C@@]4([C@](O)([C@@H](C[C@]4([C@@]3(CCC2=C1)[H])[H])O)C(CO)=O)C)O)[H])C

Molecular Formula

C21H28O6

Molecular Weight

376.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Xavier Matabosch, et al. Identification of budesonide metabolites in human urine after oral administration. Anal Bioanal Chem. 2012 Aug;404 (2) :325-40.|[2]G Jönsson, et al. Budesonide is metabolized by cytochrome P450 3A (CYP3A) enzymes in human liver. Drug Metab Dispos. 1995 Jan;23 (1) :137-42.