Anti-RAD17 Antibody

Rabbit Polyclonal Antibody specific to RAD17

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

hRad17, RF-C/activator 1 homolog

Gene Name

RAD17

NCBI Gene ID

UniProt

O75943

Cellular Locus

Nucleus

Host

Rabbit

Reactivity

Human

Immunogen

Peptide corresponding to aa 2-15 of human RAD17.

Target Antigen

Cell cycle checkpoint protein RAD17

Target

RAD17

Clonality

Polyclonal

Type

Antibody

Applications

Field of Research

Cancer research

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous rPubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12578958, PubMed:12672690, PubMed:14500819, PubMed:14624239, PubMed:15235112, PubMed:15538388, PubMed:21659603}.

Additionnal Information

Immunoblotting: use at 1:500-1:1,000 dilution. A band of approx. 69 kD is detected.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Specificity

This antibody recognizes human RAD17, a novel gene product involved in the DNA damage checkpoint signal transduction pathway. RAD17 plays a central role in cell cycle checkpoint control.