Golidocitinib

Golidocitinib (AZD4205) is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.7 μM), and shows little inhibition on JAK3 (IC50>30 μM) [1].

Product Specifications

CAS Number

[2091134-68-6]

Product Name Alternative

AZD4205

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AZD-4205.html

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H](N1CCN(C)CC1)C(NC2=C3C(C(C4=NC(NC5=CN(C)N=C5OC)=NC=C4)=CN3)=CC=C2)=O

Molecular Formula

C25H31N9O2

Molecular Weight

489.57

References & Citations

[1]Annika Birgitta Margareta ÅSTRAND, et al. Compounds and methods for inhibiting jak. WO2017050938A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

JAK1

Available Sizes

More Discoveries

Explore Other Products

Browse additional items from our catalog

SM6026S 50 µL

TLR7 (451-500) Mouse Monoclonal Antibody [Clone ID: 4F4]

View Details

K4103402 1.0 µg DNA

Akr1d1 sgRNA CRISPR Lentivector (Mouse) (Target 1)

View Details

TS404948P5 25 Slides

EFHD2 CytoSection

View Details

TU163212 1.0 mL

Miox 3'UTR GFP Stable Cell Line

View Details

SC301932 10 µg

LHX9 (NM_001014434) Human Untagged Clone

View Details

MBS176564-01 96 Well

Mouse Neprilysin/CD10 PicoKine ELISA Kit

View Details