Golidocitinib
Golidocitinib (AZD4205) is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.7 μM), and shows little inhibition on JAK3 (IC50>30 μM) [1].
Product Specifications
CAS Number
[2091134-68-6]
Product Name Alternative
AZD4205
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZD-4205.html
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H](N1CCN(C)CC1)C(NC2=C3C(C(C4=NC(NC5=CN(C)N=C5OC)=NC=C4)=CN3)=CC=C2)=O
Molecular Formula
C25H31N9O2
Molecular Weight
489.57
References & Citations
[1]Annika Birgitta Margareta ÅSTRAND, et al. Compounds and methods for inhibiting jak. WO2017050938A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
JAK1
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
61297096 4x 500 ng
LOC360919-set siRNA/shRNA/RNAi Lentivector (Rat)
Sign In for Pricing
View Details 
GTR15174086 1 Vial
Lentiviral mouse Pglyrp2 shRNA (UAS) - Lentiviral mouse Pglyrp2 shRNA (UAS, iRFP) (25)
Sign In for Pricing
View Details 
MBS7159395 Inquire
Rabbit anti-Saccharomyces cerevisiae (strain 204508/S288c)(Baker's yeast) JJJ2 Polyclonal Antibody
Sign In for Pricing
View Details RC227468L3V 200 µL
ADTRP (NM_001143948) Human Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details MPX2072K Each
Magic™ Membrane Protein Mouse Cpt1b (Carnitine palmitoyltransferase 1b, muscle) Expressed in vitro E.coli expression system, Full Length
Sign In for Pricing
View Details MBS616093-01 0.1 mL
Iron Responsive Element Binding Protein 2 (IREB2, IREBP2, ACO3, FLJ23381, Iron Regulatory Protein 2, IRP2, IRP2AD)
Sign In for Pricing
View Details