Ifosfamide

Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.

Product Specifications

CAS Number

[3778-73-2]

UNSPSC

12352005

Hazard Statement

H301, H319, H340, H350, H360

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ifosfamide.html

Purity

99.89

Solubility

DMSO : 125 mg/mL

Smiles

ClCCN1P(OCCC1)(NCCCl)=O

Molecular Formula

C7H15Cl2N2O2P

Molecular Weight

261.09

Precautions

H301, H319, H340, H350, H360

References & Citations

[1]Helal M. Prenatal effects of transplacental exposure to ifosfamide in rats. Biotech Histochem. 2016 Jul;91 (5) :357-68.|[2]Karle P, et al. Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide. Cancer Gene Ther. 2001 Mar;8 (3) :220-30.|[3]Vredenburg G, et al. Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. Toxicol Lett. 2015 Jan 5;232 (1) :182-92.