Anti-Thyroglobulin Antibody
Mouse Monoclonal Antibody specific to Thyroglobulin
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Tg
Gene Name
TG
NCBI Gene ID
<a href="https://www.ncbi.nlm.nih.gov/gene/?term=TG">TG</a>
UniProt
P01266
Cellular Locus
Secreted
Host
Mouse
Reactivity
Human
Immunogen
Purified human thyroglobulin
Target Antigen
Thyroglobulin
Target
Thyroglobulin
Clonality
Monoclonal
Isotype
IgG1
Type
Antibody
Applications
ELISA
Field of Research
Hormones/Proteins
Purification Method
PEG Purified
Concentration
Lot Specific
Dilution
Dilute in PBS or medium which is identical to that used in the assay system.
Format
Purified
Form
Liquid
Buffer
Phosphate Buffered Saline
Function
Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:32025030, PubMed:17532758). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030). {PubMed:17532758, PubMed:32025030}.
Additionnal Information
These antibodies may be used in ELISA to detect and quantitate thyroglobulin.
Storage Conditions
These antibodies are stable for at least one (1) year at -20ºC to -70ºC. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Specificity
Thyroglobulin
Formulation
PBS, pH 7.4.
Buffer pH
pH 7.4
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