Nisotirostide

Nisotirotide (LY-3457263) is a subcutaneous injectable NPY2 receptor agonist. By mimicking peptide YY (PYY), Nisotirotide inhibits appetite and can be used in the research of diseases such as obesity and diabetes[1].

Product Specifications

CAS Number

[2663844-45-7]

Product Name Alternative

LY-3457263

UNSPSC

12352209

Target

Neuropeptide Y Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nisotirostide.html

Purity

99.45

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]2N(CCC2)C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H]3N(CCC3)C([C@@H](NC([C@@H](NC([C@H]4N(CCC4)C([C@@H](NC([C@H]5NCCC5)=O)CCCCN)=O)=O)CCC(O)=O)=O)CCCCNC(CCCCCNC([C@@H](NC(CC[C@H](NC(CCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)CCC(O)=O)=O)=O)=O)=O)=O)CCC(O)=O)=O)CC(O)=O)=O)C)=O)CO)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC6=CNC7=C6C=CC=C7)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CC8=CC=C(C=C8)O)=O)CC9=CC=C(C=C9)O)=O)C)=O)CCC(O)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)CC%10=CNC=N%10)=O)CC%11=CC=C(C=C%11)O)=O)CC(C)C)=O)CC(N)=O)=O)CC%12=CNC%13=C%12C=CC=C%13)=O)CC(C)C)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)C(N)=O)C=C1

Molecular Formula

C230H343N59O65

Molecular Weight

4974.53

References & Citations

[1]Kloock S, et al. Obesity and its comorbidities, current treatment options and future perspectives: Challenging bariatric surgery? Pharmacol Ther. 2023 Nov;251:108549.