Astrophloxine

Astrophloxine is a fluorescent imaging probe capable of targeting antiparallel dimers. Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples of Alzheimer's disease (AD) mice[1].

Product Specifications

CAS Number

[14696-39-0]

UNSPSC

12352005

Hazard Statement

H315-H319

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/astrophloxine.html

Concentration

10mM

Purity

98.34

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1(C)C(/C=C/C=C2N(CC)C3=C(C=CC=C3)C\2(C)C)=[N+](CC)C4=C1C=CC=C4.[I-]

Molecular Formula

C27H33IN2

Molecular Weight

512.47

Precautions

P264-P280-P302+P352-P362+P364

References & Citations

[1]Lee JC, et al. Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory-Impairing Anti-Parallel Aβ Dimers. Angew Chem Int Ed Engl. 2020 Jul 6;59 (28) :11491-11500.