Astrophloxine
Astrophloxine is a fluorescent imaging probe capable of targeting antiparallel dimers. Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples of Alzheimer's disease (AD) mice[1].
Product Specifications
CAS Number
14696-39-0
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/astrophloxine.html
Concentration
10mM
Purity
98.34
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC1(C)C(/C=C/C=C2N(CC)C3=C(C=CC=C3)C\2(C)C)=[N+](CC)C4=C1C=CC=C4.[I-]
Molecular Formula
C27H33IN2
Molecular Weight
512.47
Precautions
P264-P280-P302+P352-P362+P364
References & Citations
[1]Lee JC, et al. Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory-Impairing Anti-Parallel Aβ Dimers. Angew Chem Int Ed Engl. 2020 Jul 6;59 (28) :11491-11500.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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