Quinine (dihydrochloride)

Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].

Product Specifications

CAS Number

[60-93-5]

UNSPSC

12352005

Hazard Statement

H302-H316-H317-H335

Target

Dengue Virus; Flavivirus; Parasite; Potassium Channel

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/quinine-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

C=C[C@H](C[N@@]1CC2)[C@H]2C[C@@H]1[C@H](O)C3=CC=NC4=CC=C(OC)C=C34.Cl.Cl

Molecular Formula

C20H26Cl2N2O2

Molecular Weight

397.34

Precautions

P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Shilu Malakar, et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25.|[2]Jhanwar, Deepika, et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate. (2016) : 2636-2640.|[3]Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23 (1) :39-44.