Endoxifen (E-isomer)

Endoxifen E-isomer (E-Endoxifen), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer exhibits antiestrogenic effects[1][2].

Product Specifications

CAS Number

[114828-90-9]

Product Name Alternative

E-Endoxifen

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Endoxifen-E-isomer.html

Concentration

10mM

Purity

98.02

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1

Molecular Formula

C25H27NO2

Molecular Weight

373.49

Precautions

H315, H319, H335

References & Citations

[1]Elkins P, et al. Characterization of the isomeric configuration and impurities of (Z) -Endoxifen by 2D NMR, high resolution LC-MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.|[2]Zheng Y, et, al. Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation. Drug Metab Dispos. 2007 Oct;35 (10) :1942-8.